Hennig J, Reuter M, Netter P, Burk C, Landt O
Center for Psychobiology and Behavioral Medicine, Department of Psychology, University of Giessen, Giessen, Germany.
Behav Neurosci. 2005 Feb;119(1):16-25. doi: 10.1037/0735-7044.119.1.16.
The authors investigated whether different types of aggression relate to the A779C tryptophan hydroxylase (TPH) polymorphism and to serotonergic activity in volunteers. A factor analysis of the Buss-Durkee Hostility Inventory yielded 2 factors representing Neurotic Hostility (NH) and Aggressive Hostility (AH). The authors used a neuroendocrine challenge with Citalopram in 48 volunteers and increased cortisol concentrations only in those with high levels of AH. Finally, an association study with 58 volunteers revealed that the A779C TPH polymorphism significantly relates to AH, with the highest aggression levels for the genotype AA and the lowest aggression levels for the genotype CC, but not to NH. Results are discussed with respect to inconsistent findings in the literature, which may be explained by this distinction of types of aggression.
作者研究了不同类型的攻击行为是否与志愿者体内的A779C色氨酸羟化酶（TPH）基因多态性及血清素能活性相关。对Buss-Durkee敌意量表进行因子分析得出了代表神经质敌意（NH）和攻击性敌意（AH）的两个因子。作者对48名志愿者进行了西酞普兰神经内分泌激发试验，结果显示只有AH水平高的志愿者皮质醇浓度升高。最后，一项针对58名志愿者的关联研究表明，A779C TPH基因多态性与AH显著相关，基因型AA的攻击水平最高，基因型CC的攻击水平最低，但与NH无关。文中结合文献中不一致的研究结果对这些结果进行了讨论，这些不一致的结果可能可以通过这种攻击行为类型的区分来解释。
