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Pleiotropic effect of the TPH A779C polymorphism on nicotine dependence and personality.

作者信息

Reuter M, Hennig J

机构信息

Department of Psychology, Center of Psychobiology and Behavioral Medicine, University of Giessen, Giessen, Germany.

出版信息

Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):20-4. doi: 10.1002/ajmg.b.30153.

DOI:10.1002/ajmg.b.30153
PMID:15635702
Abstract

Recent studies from molecular genetics have suggested an association between the tryptophan hydroxylase 1 (TPH1) gene and nicotine addiction indicating a dysfunction of the serotonergic (5-HT) system in smoking behavior. In a sample of 252 healthy subjects, a significant association between variations observed in nicotine dependence and the heterozygous AC-genotype of the TPH A779C polymorphism could be demonstrated. Moreover, the heterozygous genotype was significantly associated with a personality trait of neurotic aggression (indirect hostility, negativism), as measured by the Buss-Durkee-Hostility-Inventory (BDHI). The positive heterosis effects with respect to nicotine addiction and personality support the idea that the TPH1 gene exerts pleiotropic effects.

摘要

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