New A S, Gelernter J, Yovell Y, Trestman R L, Nielsen D A, Silverman J, Mitropoulou V, Siever L J
Psychiatry Service, Bronx Veterans Administration Medical Center, New York 10468, USA.
Am J Med Genet. 1998 Feb 7;81(1):13-7. doi: 10.1002/(sici)1096-8628(19980207)81:1<13::aid-ajmg3>3.0.co;2-o.
To assess the relationship between two phenotypes in an extremely well-characterized population of personality disorder patients-impulsive aggression and prolactin response to fenfluramine-and tryptophan hydroxylase (TPH) genotype, TPH genotype (at an intronic polymorphic site) and prolactin response to fenfluramine were assessed in 40 Caucasian patients with personality disorder. Impulsive aggression was assessed by using the Buss-Durkee Hostility Inventory (BDHI). Twenty-one male patients with the "LL" genotype had higher BDHI scores than men with the "UL" or the "UU" genotype. No relationship between genotype and prolactin response to fenfluramine was found. It was concluded that impulsive-aggressive behavior in male personality disorder patients may be associated with the TPH genotype.
为了评估在一组特征极为明确的人格障碍患者群体中两种表型——冲动攻击性与对芬氟拉明的催乳素反应——与色氨酸羟化酶（TPH）基因型之间的关系，研究人员对40名患有精神障碍的白种人患者的TPH基因型（在内含子多态性位点）和对芬氟拉明的催乳素反应进行了评估。冲动攻击性通过使用布斯-杜克敌意量表（BDHI）进行评估。21名具有“LL”基因型的男性患者的BDHI得分高于具有“UL”或“UU”基因型的男性。未发现基因型与对芬氟拉明的催乳素反应之间存在关联。研究得出结论，男性人格障碍患者的冲动攻击行为可能与TPH基因型有关。
