Lee Inah, Hunsaker Michael R, Kesner Raymond P
Center for Memory and Brain, Boston University, Boston, MA, USA.
Behav Neurosci. 2005 Feb;119(1):145-53. doi: 10.1037/0735-7044.119.1.145.
Previous literature suggests that the hippocampus subserves processes associated with the encoding of novel information. To investigate the role of different subregions of the hippocampus, the authors made neurotoxic lesions in different subregions of the dorsal hippocampus (i.e., CA1, dentate gyrus [DG], or CA3) of rats, followed by tests using a spontaneous object exploration paradigm. All lesion groups explored normally an object newly introduced in a familiar location. However, when some of the familiar objects were moved to novel locations, both DG and CA3 lesion groups were severely impaired in reexploring the displaced objects, whereas the CA1 lesion group was only mildly impaired in reexploration. The results suggest that the DG-CA3 network is essential in detecting novelty for spatial, but not for individual object, information.
以往文献表明，海马体参与与新信息编码相关的过程。为了研究海马体不同亚区的作用，作者对大鼠背侧海马体的不同亚区（即CA1、齿状回[DG]或CA3）进行了神经毒性损伤，随后使用自发物体探索范式进行测试。所有损伤组都能正常探索在熟悉位置新引入的物体。然而，当一些熟悉的物体被移到新位置时，DG和CA3损伤组在重新探索被移动的物体时严重受损，而CA1损伤组在重新探索时仅轻度受损。结果表明，DG-CA3网络对于检测空间信息的新奇性至关重要，但对于单个物体信息则不然。
