Nguyen Nguyen D, Pongchaiyakul Chatlert, Center Jacqueline R, Eisman John A, Nguyen Tuan V
Bone and Mineral Research Program, Garvan Institute of Medical Research, St Vincent's Hospital, Sydney, UNSW, Australia.
BMC Musculoskelet Disord. 2005 Feb 23;6:11. doi: 10.1186/1471-2474-6-11.
Fat mass, which is a major component of body weight, is directly related to bone mineral density and reduced fracture risk. It is not known whether abdominal fat is associated with hip fracture. The present study was designed to examine the association between abdominal fat and hip fracture in women and men aged 60+ years.
This was a nested case-control study with one fracture case being matched with two controls of the same age. In women 63 cases were matched with 126 controls, and in men 26 cases were matched with 52 controls. Hip fracture was confirmed by X-ray and personal interview. Other measurements included weight, height, body mass index (BMI), abdominal fat, and femoral neck bone density (FNBMD). Conditional logistic regression model was used to analyse data.
The odds ratio of hip fracture risk associated with each 10% lower abdominal fat was 1.5 (95% CI, 1.1 to 2.1) in women and 1.2 (95% CI, 0.7 to 2.0) in men. However after adjusting for FNBMD or body weight, the abdominal fat-fracture association was no longer statistically significant. Similarly, body weight and BMI was each significantly associated with hip fracture risk (in women), but after taking with account the effect of FNBMD, the association become statistically non-significant.
Lower abdominal fat was associated with an increased risk of hip fracture in elderly women, but the association was not independent of FNBMD or weight. The contribution of abdominal fat to hip fracture risk is likely to be modest.
脂肪量是体重的主要组成部分，与骨矿物质密度直接相关，并降低骨折风险。目前尚不清楚腹部脂肪是否与髋部骨折有关。本研究旨在探讨60岁及以上女性和男性腹部脂肪与髋部骨折之间的关联。
这是一项巢式病例对照研究，1例骨折病例与2例同年龄的对照进行匹配。在女性中，63例病例与126例对照匹配，在男性中，26例病例与52例对照匹配。通过X线检查和个人访谈确诊髋部骨折。其他测量指标包括体重、身高、体重指数（BMI）、腹部脂肪和股骨颈骨密度（FNBMD）。采用条件逻辑回归模型分析数据。
腹部脂肪每降低10%，女性髋部骨折风险的比值比为1.5（95%可信区间，1.1至2.1），男性为1.2（95%可信区间，0.7至2.0）。然而，在调整FNBMD或体重后，腹部脂肪与骨折的关联不再具有统计学意义。同样，体重和BMI在女性中均与髋部骨折风险显著相关，但在考虑FNBMD的影响后，这种关联不再具有统计学意义。
下腹部脂肪与老年女性髋部骨折风险增加有关，但这种关联并非独立于FNBMD或体重。腹部脂肪对髋部骨折风险的影响可能较小。
