Ishida T, Takami M
Department of Orthopaedic Surgery, Osaka City University Medical School, Japan.
Int Orthop. 1992;16(1):59-61. doi: 10.1007/BF00182987.
Preoperative chemotherapy before limb-sparing surgery for osteosarcoma is used to reduce the size of the tumour, facilitate removal and prevent distant metastases. Fifteen patients with osteosarcoma were treated with six different protocols. Assessment of the clinical and radiological size of the lesion, of the histology of the resected specimen and of serum alkaline phosphatase levels were done. Greatest control of the tumour was obtained with the intravenous use of cisplatin, three times at intervals of three weeks before surgery, compared to the use of adriamycin or methotrexate in other protocols. Prompt surgery after preoperative chemotherapy and postoperative chemotherapy are advised.
骨肉瘤保肢手术前的术前化疗用于缩小肿瘤大小、便于切除并预防远处转移。15例骨肉瘤患者接受了6种不同方案的治疗。对病变的临床和放射学大小、切除标本的组织学以及血清碱性磷酸酶水平进行了评估。与其他方案中使用阿霉素或甲氨蝶呤相比，术前静脉使用顺铂，在手术前三周间隔三次使用，对肿瘤的控制效果最佳。建议在术前化疗后及时进行手术，并进行术后化疗。
