• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

药物在脊柱结核病灶中的渗透情况。

The penetration of drugs into the lesions of spinal tuberculosis.

作者信息

Kumar K

机构信息

Department of Orthopaedics, Krishna Institute of Medical Sciences, Karad Maharashtra State, India.

出版信息

Int Orthop. 1992;16(1):67-8. doi: 10.1007/BF00182989.

DOI:10.1007/BF00182989
PMID:1572775
Abstract

The concentration of antituberculous drugs in blood and pus from tuberculous spinal lesions was measured initially, and again after 3 to 5 months of treatment in 4 cases. The pre- and post-chemotherapy drug concentrations were almost the same. This indicated that healing does not interfere with the penetration of the drugs into the lesion.

摘要

最初对4例结核性脊柱病变患者血液和脓液中的抗结核药物浓度进行了测定，并在治疗3至5个月后再次进行测定。化疗前后的药物浓度几乎相同。这表明愈合过程不会干扰药物渗入病变部位。

相似文献

1
The penetration of drugs into the lesions of spinal tuberculosis.药物在脊柱结核病灶中的渗透情况。
Int Orthop. 1992;16(1):67-8. doi: 10.1007/BF00182989.
2
[Multislice-CT diagnosis of complications of tuberculous spondylodiscitis].[多层螺旋CT对结核性脊椎椎间盘炎并发症的诊断]
Rofo. 2005 Sep;177(9):1305-7. doi: 10.1055/s-2005-858390.
3
Penetration of isoniazid, rifampicin and pyrazinamide in tuberculous pleural effusion and psoas abscess.异烟肼、利福平和吡嗪酰胺在结核性胸腔积液和腰大肌脓肿中的渗透。
Int J Tuberc Lung Dis. 2004 Nov;8(11):1368-72.
4
Disseminated tuberculosis after pregnancy progressed to paradoxical response to the treatment: report of two cases.
BMC Infect Dis. 2016 Jun 13;16:284. doi: 10.1186/s12879-016-1624-x.
5
Tuberculous spondylodiskitis with lumbar tumor.结核性腰椎间盘炎伴腰椎肿瘤
Reumatol Clin. 2012 Sep-Oct;8(5):292-3. doi: 10.1016/j.reuma.2011.10.011. Epub 2011 Dec 30.
6
Surgical treatment for spinal tuberculosis with bilateral paraspinal abscess or bilateral psoas abscess: one-stage surgery.双侧椎旁脓肿或双侧腰大肌脓肿的脊柱结核手术治疗：一期手术。
J Spinal Disord Tech. 2014 Dec;27(8):E309-14. doi: 10.1097/BSD.0000000000000120.
7
A gibbus in puerperium.产褥期脊柱后凸
BMJ Case Rep. 2008;2008:bcr0620080154. doi: 10.1136/bcr.06.2008.0154. Epub 2008 Nov 20.
8
Two cases of pott disease associated with bilateral psoas abscesses: case report.两例伴有双侧腰大肌脓肿的波特病：病例报告
Spine (Phila Pa 1976). 2006 Jul 15;31(16):E561-4. doi: 10.1097/01.brs.0000225998.99872.7f.
9
Distribution of three antituberculous drugs and their metabolites in different parts of pathological vertebrae with spinal tuberculosis.三种抗结核药物及其代谢物在脊柱结核病理性椎骨不同部位的分布。
Spine (Phila Pa 1976). 2011 Sep 15;36(20):E1290-5. doi: 10.1097/BRS.0b013e31820beae3.
10
Disseminated Tuberculosis in an Immunocompetent State: A Case Report.免疫功能正常状态下的播散性肺结核：一例报告
Infect Disord Drug Targets. 2023;23(2):e210922209022. doi: 10.2174/1871526522666220921123920.

引用本文的文献

1
Comparison of anterior, posterior, and anterior combined with posterior surgical treatment of thoracic and lumbar spinal tuberculosis: a systematic review.胸腰椎脊柱结核前路、后路及前后联合手术治疗的比较：一项系统评价
J Int Med Res. 2020 Feb;48(2):300060519830827. doi: 10.1177/0300060519830827. Epub 2019 Mar 17.
2
[Treatment of thoracolumbar spinal tuberculosis by posterior focus debridement and bone grafting and fixation combined with psoas abscess debridement and local chemotherapy via different approachs].[后路病灶清除植骨内固定联合不同入路腰大肌脓肿清创及局部化疗治疗胸腰椎脊柱结核]
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2018 Jul 15;32(7):912-919. doi: 10.7507/1002-1892.201801068.
3

本文引用的文献

1
Studies on streptomycin levels of blood and abscess.血液和脓肿中链霉素水平的研究。
Acta Tuberc Scand. 1960;38:40-50.
2
The chemotherapy of bone and joint tuberculosis. II. Observations on clinical diseases.骨与关节结核的化学疗法。II. 临床疾病观察
Ann Tuberc. 1954 Oct;5(2):59-94.
3
Studies on the concentration of streptomycin the treatment of bone and joint tuberculosis.链霉素浓度用于骨与关节结核治疗的研究。
Spinal tuberculosis, natural history of disease, classifications and principles of management with historical perspective.
脊柱结核、疾病的自然史、分类及治疗原则：历史视角
Eur J Orthop Surg Traumatol. 2016 Aug;26(6):551-8. doi: 10.1007/s00590-016-1811-x. Epub 2016 Jul 19.
4
One-stage surgical management for tuberculosis of the upper cervical spine by posterior debridement, short-segment fusion, and posterior instrumentation in children.一期后路清创、短节段融合、后路内固定术治疗儿童上颈椎结核。
Eur Spine J. 2013 Jan;22(1):72-8. doi: 10.1007/s00586-012-2544-0. Epub 2012 Oct 21.
5
One-stage posterior focus debridement, fusion, and instrumentation in the surgical treatment of cervicothoracic spinal tuberculosis with kyphosis in children: a preliminary report.一期后路病灶清除、融合及内固定术治疗儿童颈胸段脊柱结核伴后凸畸形：初步报告
Childs Nerv Syst. 2011 May;27(5):735-42. doi: 10.1007/s00381-010-1319-3. Epub 2010 Nov 6.
6
Simultaneous anterior and posterior surgery in the management of tuberculous spondylitis with psoas abscess in patients with neurological deficits.合并腰大肌脓肿的结核性脊柱炎伴神经功能缺损患者的前后路同期手术治疗
Asian Spine J. 2008 Dec;2(2):94-101. doi: 10.4184/asj.2008.2.2.94. Epub 2008 Dec 31.
Acta Tuberc Scand. 1952;27(3-5):176-89.
4
Distribution and excretion of radioactive isoniazid in tuberculous patients.放射性异烟肼在结核病患者体内的分布与排泄
J Am Med Assoc. 1953 Apr 18;151(16):1384-8.
5
Experimental skeletal tuberculosis in the guineapig. A method for producing local lesions and an autoradiographic study of their accessibility to tritium-labelled dihydrostreptomycin.豚鼠实验性骨结核。产生局部病变的方法及其对氚标记二氢链霉素摄取情况的放射自显影研究。
Acta Orthop Scand. 1967:Suppl 98:11-80. doi: 10.3109/ort.1967.38.suppl-98.01.
6
Penetration of antitubercular drugs in clinical osteoarticular tubercular lesions.抗结核药物在临床骨关节结核病变中的渗透情况。
Acta Orthop Scand. 1977;48(4):362-8. doi: 10.3109/17453677708992009.