Tuli S M, Kumar K, Sen P C
Acta Orthop Scand. 1977;48(4):362-8. doi: 10.3109/17453677708992009.
In 79 consecutive cases of skeletal tuberculosis the concentration of streptomycin and ethambutol was analysed. The material for analysis was obtained from the diseased joints of 14 patients and from cold abscesses from spinal or osseous lesions in 65 patients. The concentration of the drugs in the serum and in the tuberculous material was measured 3 hours after the systemic administration of the drugs in therapeutic doses. The concentration was expressed as microgram per ml of the tuberculous material and the data were subjected to statistical analysis. Streptomycin and ethambutol penetrated freely into the tuberculous joints; their concentration in the cold abscesses, however, was half to one third of the concentration in the serum. There was a wide range of concentrations; however, in the tuberculous joints as well as in the cold abscesses the concentrations were much higher than those considered to have an inhibitory effect on mycobacterium tuberculosis in clinical material.
对79例连续性骨结核病例进行了链霉素和乙胺丁醇浓度分析。分析材料取自14例患者的患病关节以及65例患者脊柱或骨质病变处的寒性脓肿。在以治疗剂量全身给药3小时后，测量血清和结核病灶材料中的药物浓度。浓度以每毫升结核病灶材料中所含微克数表示，并对数据进行统计分析。链霉素和乙胺丁醇可自由渗透至结核关节；然而，它们在寒性脓肿中的浓度仅为血清浓度的二分之一至三分之一。浓度范围较宽；不过，在结核关节以及寒性脓肿中，这些浓度远高于临床材料中被认为对结核分枝杆菌有抑制作用的浓度。
