Ayaslioglu Ergin, Tekeli Emin, Birengel Serhat
Department of Infectious Diseases and Clinical Microbiology, Kirikkale University Faculty of Medicine, Kirikkale, Turkey.
Jpn J Infect Dis. 2005 Feb;58(1):11-4.
Activation of macrophages represents one of the initial events in innate immunity to intracellular infections. CD14 is expressed principally by cells of monocyte/macrophage lineage and plays a pivotal role in innate recognition of bacterial cell wall components, particularly lipopolysaccharides. We measured serum concentrations of soluble CD14 (sCD14) in serum samples obtained from 37 patients with brucellosis and 36 healthy controls. Serum levels of sCD14 were significantly increased in patients with brucellosis compared with those in healthy controls (P < 0.001). Re-analysis of serum samples after treatment in 25 patients demonstrated that treatment did not result in any significant decline in sCD14 levels. Despite a limited study population, these findings may implicate CD14 signaling as an important component of the initial anti-brucellar host response and suggest that activation of mononuclear phagocytic system is sustained even following effective treatment.
巨噬细胞的激活是细胞内感染固有免疫的初始事件之一。CD14主要由单核细胞/巨噬细胞谱系的细胞表达，在细菌细胞壁成分尤其是脂多糖的固有识别中起关键作用。我们检测了37例布鲁氏菌病患者和36名健康对照者血清样本中可溶性CD14（sCD14）的浓度。与健康对照者相比，布鲁氏菌病患者的血清sCD14水平显著升高（P < 0.001）。对25例患者治疗后的血清样本进行重新分析发现，治疗并未导致sCD14水平出现任何显著下降。尽管研究人群有限，但这些发现可能表明CD14信号传导是初始抗布鲁氏菌宿主反应的重要组成部分，并提示即使在有效治疗后，单核吞噬系统的激活仍持续存在。
