Division of Pharmacognosy and Toxicology, Faculty of Pharmaceutical Sciences, Khon Kaen University, Khon Kaen 40002, Thailand.
ICBAS-Instituo de Ciências Biomédicas Abel Salazar and CIIMAR, Universidade do Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Molecules. 2022 May 7;27(9):3014. doi: 10.3390/molecules27093014.
The present study describes investigation of the effects of the bark resin extract of (Clusiaceae) on the cognitive function and the induction of oxidative stress in both frontal cortex and hippocampus by unpredictable chronic mild stress (UCMS). By using behavioral mouse models, i.e., the Y-maze test, the Novel Object Recognition Test (NORT), and the Morris Water Maze Test (MWMT), it was found that the negative impact of repeated mild stress-induced learning and memory deficit through brain oxidative stress in the UCMS mice was reversed by treatment with the bark resin extract . Moreover, the prenylated xanthones cowagarcinone C, cowaxanthone, α-mangostin, cowaxanthone B, cowanin, fuscaxanthone A, fuscaxanthone B, xanthochymusxanthones A, 7--methylgarcinone E, and cowagarcinone A, isolated from the bark resin of , were assayed for their inhibitory activities against β-amyloid (Aβ) aggregation and monoamine oxidase enzymes (MAOs).
本研究描述了（藤黄科）树皮树脂提取物对不可预测慢性轻度应激（UCMS）诱导的前额叶皮层和海马体氧化应激对认知功能的影响。通过使用行为学小鼠模型，即 Y 迷宫测试、新物体识别测试（NORT）和 Morris 水迷宫测试（MWMT），发现通过脑氧化应激重复轻度应激诱导的学习和记忆缺陷对 UCMS 小鼠的负面影响可通过树皮树脂提取物的治疗逆转。此外，从树皮树脂中分离得到的 7 种 1,3-二氢-2H-苯并吡喃-2-酮，即黄烷酮、牛黄烷酮 C、α-倒捻子素、牛黄烷酮 B、考瓦宁、fuscaxanthone A、fuscaxanthone B、xanthochymusxanthones A、7--甲基garcinone E 和 cowagarcinone A，对其抑制β-淀粉样蛋白（Aβ）聚集和单胺氧化酶（MAO）的活性进行了测定。
