Lu Cheng-Chan, Chen Jung-Chin, Tsai Sen-Tien, Jin Ying-Tai, Tsai Jui-Chen, Chan Shih-Huang, Su Ih-Jen
Department of Pathology, National Cheng Kung University, Tainan, Taiwan.
Int J Cancer. 2005 Jul 10;115(5):742-6. doi: 10.1002/ijc.20946.
Nasopharyngeal carcinoma (NPC) is an epithelial tumor uniquely prevalent in southern Chinese. HLA-A2 is associated with NPC. In a previous study, we showed that the genes associated with susceptibility to NPC are primarily located within the HLA-A locus in Taiwanese NPC patients. However, the pathogenic genes causing NPC susceptibility remain unknown. Here, 8 polymorphic microsatellite markers distributed over a 1 megabase region surrounding the HLA-A locus were subjected to genetic analysis for the NPC-susceptibility locus. Statistical studies of associated alleles detected on each microsatellite locus showed that the NPC- susceptibility genes are most likely located between the D6S510 and D6S211 markers within a 132 kb segment containing the HLA-A locus. These results undoubtedly would facilitate the further positional cloning of the NPC-susceptibility locus, which has been elusive for the past 30 years.
鼻咽癌（NPC）是一种在中国南方尤为常见的上皮性肿瘤。HLA - A2与鼻咽癌相关。在先前的一项研究中，我们表明，台湾鼻咽癌患者中与鼻咽癌易感性相关的基因主要位于HLA - A基因座内。然而，导致鼻咽癌易感性的致病基因仍然未知。在此，对分布在HLA - A基因座周围1兆碱基区域的8个多态性微卫星标记进行了鼻咽癌易感基因座的遗传分析。对每个微卫星基因座上检测到的相关等位基因的统计研究表明，鼻咽癌易感基因最有可能位于包含HLA - A基因座的132 kb片段内的D6S510和D6S211标记之间。这些结果无疑将有助于对过去30年来一直难以捉摸的鼻咽癌易感基因座进行进一步的定位克隆。
