来自纸莎草乳香的生物活性成分。

Bioactive constituents from Boswellia papyrifera.

作者信息

Naz Humera, Makhmoor Talat, Yasin Amsha, Fatima Naheed, Ngounou F N, Kimbu S F, Sondengam B L, Choudhary M Iqbal

机构信息

H. E. J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi-75270, Pakistan.

出版信息

J Nat Prod. 2005 Feb;68(2):189-93. doi: 10.1021/np040142x.

DOI:10.1021/np040142x

PMID:15730241

Abstract

Phytochemical investigation of the stem bark extract of Boswellia papyrifera afforded two new stilbene glycosides, trans-4',5-dihydroxy-3-methoxystilbene-5-O-{alpha-L-rhamnopyranosyl-(1-->2)-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (1), trans-4',5-dihydroxy-3-methoxystilbene-5-O-[alpha-L-rhamnopyranosyl-(1-->6)]-beta-D-glucopyranoside (2), and a new triterpene, 3alpha-acetoxy-27-hydroxylup-20(29)-en-24-oic acid (3), along with five known compounds, 11-keto-beta-boswellic acid (4), beta-elemonic acid (7), 3alpha-acetoxy-11-keto-beta-boswellic acid (8), beta-boswellic acid (9), and beta-sitosterol (10). The stilbene glycosides exhibited significant inhibition of phosphodiesterase I and xanthine oxidase. The triterpenes (3-9) exhibited prolyl endopeptidase inhibitory activities.

摘要

对纸莎草乳香茎皮提取物进行植物化学研究，得到了两种新的芪糖苷，反式-4',5-二羟基-3-甲氧基芪-5-O-{α-L-鼠李吡喃糖基-(1→2)-[α-L-鼠李吡喃糖基-(1→6)]-β-D-葡萄糖吡喃糖苷（1）、反式-4',5-二羟基-3-甲氧基芪-5-O-[α-L-鼠李吡喃糖基-(1→6)]-β-D-葡萄糖吡喃糖苷（2），以及一种新的三萜，3α-乙酰氧基-27-羟基羽扇豆-20(29)-烯-24-酸（3），同时还得到了五种已知化合物，11-酮-β-乳香酸（4）、β-榄香烯酸（7）、3α-乙酰氧基-11-酮-β-乳香酸（8）、β-乳香酸（9）和β-谷甾醇（10）。芪糖苷对磷酸二酯酶I和黄嘌呤氧化酶表现出显著抑制作用。三萜类化合物（3 - 9）表现出脯氨酰内肽酶抑制活性。