Hussein Ahmed A, Barberena Icela, Correa Mireya, Coley Phyllis D, Solis Pablo N, Gupta Mahabir P
Centro de Investigaciones Farmacognósticas de la Flora Panameña (CIFLORPAN), Facultad de Farmacia, Universidad de Panamá, Apartado 10767, Estafeta Universitaria, Panamá, República de Panamá.
J Nat Prod. 2005 Feb;68(2):231-3. doi: 10.1021/np049803g.
Three new compounds, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4-oxo-4H-chromen-3-yl-4,6-bis-O-beta-D-(3,4,5-trihydroxybenzoyl)glucopyranoside (1), 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl-5-O-alpha-L-(3,4,5-trihydroxybenzoyl)arabinofuranoside (2), and 2-hydroxy-4-O-alpha-L-(3,5,7-trihydroxy-4-oxo-4H-chromen-2-yl)phenylarabinofuranoside (3), were isolated from the young leaves of Triplaris cumingiana, together with two known compounds, quercetin 3-O-alpha-L-(5"-O-galloyl)arabinofuranoside (4) and quercetin 3-O-beta-D-(6"-O-galloyl)glucopyranoside (5). The structures of 1-3 were established by spectroscopic methods. Compounds 1-5 were evaluated for their cytotoxic activities against the MCF-7, H-460, and SF-268 human cancer cell lines.
从库氏刺果藤的幼叶中分离出三种新化合物，即2-(3,4-二羟基苯基)-5,7-二羟基-4-氧代-4H-色烯-3-基-4,6-双-O-β-D-(3,4,5-三羟基苯甲酰基)吡喃葡萄糖苷(1)、5,7-二羟基-2-(4-羟基苯基)-4-氧代-4H-色烯-3-基-5-O-α-L-(3,4,5-三羟基苯甲酰基)阿拉伯呋喃糖苷(2)和2-羟基-4-O-α-L-(3,5,7-三羟基-4-氧代-4H-色烯-2-基)苯基阿拉伯呋喃糖苷(3)，以及两种已知化合物，槲皮素3-O-α-L-(5″-O-没食子酰基)阿拉伯呋喃糖苷(4)和槲皮素3-O-β-D-(6″-O-没食子酰基)吡喃葡萄糖苷(5)。通过光谱方法确定了1-3的结构。对化合物1-5针对MCF-7、H-460和SF-268人癌细胞系的细胞毒性活性进行了评估。
