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[肾移植术后的手术并发症]

[Surgical complications after kidney transplantation].

作者信息

Risaliti A, Sainz-Barriga M, Baccarani U, Adani G L, Montanaro D, Gropuzzo M, Tullissi P, Boscutti G, Lorenzin D, Mioni G, Bresadola F

机构信息

Unita' Trapianti, Clinica Chirurgica dell'Universita' degli Studi di Udine, P.U.G.D.

出版信息

G Ital Nefrol. 2004 Jan-Feb;21 Suppl 26:S43-7.

Abstract

Chronic renal failure needs substitutive treatment such as haemodialysis and peritoneal dialysis for the patient to survive. Kidney transplantation (KTx) improves survival of the patient with chronic renal failure. Since the first KTx, performed by Merrill in Boston in 1959, advances in medical therapy, immunosuppressive therapy and refinements in surgical technique have improved the quality of life of the transplant patient. We present a review of the incidence, diagnosis and therapy of surgical complications after KTx reported in the literature and a retrospective analysis of 297 consecutive cadaveric donor kidney transplants done in our institution from September 1993 to September 2002. Vascular complications represent 5-10% of postoperative complications. Our experience showed an incidence of 1.7% renal artery thrombosis, 1.4% renal vein thrombosis, 1.7% renal artery stenosis, 1.4% arterial rupture due to fungal arteritis, 0.7% spontaneous graft ruptures and 12% lymphoceles. Urological complications account for 10-15% of postoperative complications. In our series we found an incidence of 7.4% urinary leakage, 2.7% urinary obstruction and 3% urinary reflux. Gastrointestinal complications represent 16% of postoperative complications. Our series showed 1% pancreatitis with an overall mortality of 33% and an incidence of 1.7% intestinal perforations. Surgical complications still represent a challenge that increments morbidity and mortality among kidney transplant recipients. Data shown may offer some guidance on how to deal with early and late post-transplant surgical complications.

摘要

慢性肾衰竭需要诸如血液透析和腹膜透析等替代治疗,以使患者存活。肾移植可提高慢性肾衰竭患者的生存率。自1959年梅里尔在波士顿完成首例肾移植以来,药物治疗、免疫抑制治疗的进展以及手术技术的改进提高了移植患者的生活质量。我们对文献中报道的肾移植术后手术并发症的发生率、诊断和治疗进行综述,并对1993年9月至2002年9月在我们机构连续进行的297例尸体供肾移植进行回顾性分析。血管并发症占术后并发症的5%-10%。我们的经验显示,肾动脉血栓形成的发生率为1.7%,肾静脉血栓形成的发生率为1.4%,肾动脉狭窄的发生率为1.7%,真菌性动脉炎导致的动脉破裂发生率为1.4%,移植肾自发性破裂发生率为0.7%,淋巴囊肿发生率为12%。泌尿系统并发症占术后并发症的10%-15%。在我们的系列研究中,我们发现尿漏发生率为7.4%,尿路梗阻发生率为2.7%,尿反流发生率为3%。胃肠道并发症占术后并发症的16%。我们的系列研究显示,胰腺炎发生率为1%,总体死亡率为33%,肠穿孔发生率为1.7%。手术并发症仍然是一个挑战,会增加肾移植受者的发病率和死亡率。所展示的数据可能为如何处理移植术后早期和晚期手术并发症提供一些指导。

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