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[肾移植术后的外科泌尿并发症]

[Surgical-urologic complications after kidney transplantation].

作者信息

Dreikorn K, Horsch R, Rössler W

出版信息

Urologe A. 1982 Sep;21(5):256-64.

PMID:6758277
Abstract

The incidence, pathogenesis, diagnostic procedures and management of surgical and urological complications observed in 437 consecutive renal transplantations are described. Urinary fistulas (4.3%) and ureteral obstructions (1.8%) are the most important urological complications. Prompt diagnosis and correction are mandatory to prevent graft loss and death of the recipient, especially if these complications are associated with infection. A high incidence of reflux into the graft (37.6%) was detected by routine cysto-urethrogram. For the first time a correlation between the incidence of reflux and the number of rejection episodes could be demonstrated, suggesting immunological alterations of the transplant ureter as the main pathogenetic factor of reflux after renal transplantation. However, reflux does not seem to be deleterious to graft prognosis, provided there is no subvesical obstruction. The main surgical complications after renal transplantation are lyymphoceles (8.2%), renal artery stenoses (6.7%), and spontaneous graft ruptures (4.3%), while wound infections (1.8%) and arterial thromboses resp. ruptures (0.7% resp. 0.5%) are rare complications. Urological and surgical complications can be kept to a minimum by strict adherence to certain principles in pretransplant recipient evaluation, donor nephrectomy (in situ perfusion, en bloc nephrectomy) and the technique of graft implantation. The extravesical technique of uretero-neocystostomy is the procedure of choice for the reconstruction of the urinary tract in renal transplantation.

摘要

本文描述了在437例连续肾移植中观察到的外科和泌尿外科并发症的发生率、发病机制、诊断方法及处理。尿瘘(4.3%)和输尿管梗阻(1.8%)是最重要的泌尿外科并发症。及时诊断和纠正对于防止移植物丢失和受者死亡至关重要,尤其是当这些并发症与感染相关时。通过常规膀胱尿道造影检测到移植肾反流发生率较高(37.6%)。首次证明了反流发生率与排斥反应次数之间的相关性,提示移植输尿管的免疫改变是肾移植后反流的主要发病因素。然而,只要没有膀胱下梗阻,反流似乎对移植物预后无害。肾移植后的主要外科并发症是淋巴囊肿(8.2%)、肾动脉狭窄(6.7%)和移植肾自发性破裂(4.3%),而伤口感染(1.8%)和动脉血栓形成及破裂(分别为0.7%和0.5%)是罕见并发症。通过在移植前受者评估、供肾切除(原位灌注、整块肾切除)及移植物植入技术中严格遵循某些原则,可将泌尿外科和外科并发症降至最低。膀胱外输尿管-新膀胱吻合术是肾移植中尿路重建的首选方法。

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