Martel P, Bernard J D, Roumagnac M, Bonnet F, David J M
Unité de Gynécologie, Centre Claudius-Regaud, Toulouse.
J Gynecol Obstet Biol Reprod (Paris). 1992;21(1):23-9.
Fifty-nine conisations and 25 vaporizations were carried out using laser CO2 in order to treat a series of 84 cases of severe dysplasias (CIN III). After a follow-up of 4 and 12 months (median period of observation 25 months) it was found that out of 74 patients that were followed up in this way 72 had benefitted from the use of the treatment. There were 5 cases however of recurrence of dysplasia (1 CIN I, 2 CIN II, 2 CIN III). These had further treatment with laser. Four of those were controlled properly, the fifth had to have surgery. Complications of treatment did not occur when vaporization was used and only rarely when conisation was used. With vaporisation it is not possible to obtain a piece for histological examination, but if it is done according to precise criteria it is safe (7 mm depth at least and vaporisation carried out to 3 mm beyond the lesions). It can be used particularly in young patients who have never been pregnant. If these have been examined carefully with directed biopsies taken colposcopically and where the lesion is strictly limited to the exocervix and the transformation zone has been seen and the lesion is small (2 cm of less), 84% were controlled therapeutically and using Bruhat's criteria the success rate was 96%. Conisation was effective for every one of the other cases. Laser CO2 probably lessens local complications of the procedure and if vaporization is carried out on the rim of the cervix better control of the condition is obtained (98% controlled in the period under review).
为治疗84例重度发育异常(CIN III)患者,使用二氧化碳激光进行了59次锥形切除术和25次汽化术。经过4个月和12个月的随访(中位观察期25个月),发现在以这种方式随访的74例患者中,有72例从治疗中受益。然而,有5例发育异常复发(1例CIN I,2例CIN II,2例CIN III)。这些患者接受了进一步的激光治疗。其中4例得到了妥善控制,第5例不得不接受手术。使用汽化术时未发生治疗并发症,使用锥形切除术时仅偶尔发生。采用汽化术无法获取组织样本进行组织学检查,但如果按照精确标准操作则是安全的(至少7毫米深度,在病变外3毫米处进行汽化)。它特别适用于从未怀孕的年轻患者。如果通过阴道镜引导下活检仔细检查这些患者,且病变严格局限于宫颈外口,已观察到转化区且病变较小(2厘米及以下),84%的患者得到了治疗控制,按照布鲁阿标准成功率为96%。锥形切除术对其他所有病例均有效。二氧化碳激光可能会减少手术的局部并发症,如果在宫颈边缘进行汽化术,则能更好地控制病情(在本观察期内98%得到控制)。