Sadoul G, Beuret T, Barbagelatta M
J Gynecol Obstet Biol Reprod (Paris). 1984;13(6):681-90.
The authors have used the CO2 laser for the treatment of cervical lesions since 1979. 475 cases were treated, of whom three-quarters were suffering from dysplasia or carcinoma in situ. The cases were discovered by smears from the cervix and vagina and by colposcopy and were confirmed by biopsy. The ways in which the treatment could be conducted depended on the site and not on the severity of the lesion so long as cases of micro-invasion were excluded. When the lesion was sited on the ectocervix the treatment consisted, after taking a small biopsy for histological checking, in the destruction of the lesion using a laser attached to a microscope. When the lesion was endocervical conisation had to be carried out using a laser attached to an apparatus held in the hand. Colposcopic examination carried out 15 to 20 days after treatment made it possible to discover whether the treatment had been complete or not. Recurrences are characterised by the return of colposcopic and cytological abnormalities. Sometimes these are only cytological and may occur 6 to 18 months after treatment. After 5 years the level of recurrences is remarkably low and is less than 4 per cent. Secondary complications such as haemorrhage are very rare, and the morphology of the cervix is hardly changed except in a few cases. The operator must know very well indeed how to use the colposcope to undertake such treatments successfully,
自1979年以来,作者们一直使用二氧化碳激光治疗宫颈病变。共治疗了475例患者,其中四分之三患有发育异常或原位癌。这些病例通过宫颈和阴道涂片以及阴道镜检查发现,并经活检确诊。只要排除微侵袭病例,治疗方法取决于病变部位而非病变严重程度。当病变位于宫颈外口时,在取一小块组织进行组织学检查后,使用连接显微镜的激光破坏病变。当病变位于宫颈管内时,则必须使用手持器械连接的激光进行宫颈锥切术。治疗后15至20天进行阴道镜检查,以确定治疗是否彻底。复发的特征是阴道镜和细胞学异常再次出现。有时仅为细胞学异常,可能在治疗后6至18个月出现。5年后复发率极低,低于4%。出血等继发性并发症非常罕见,除少数病例外,宫颈形态几乎没有改变。操作者必须非常熟练地使用阴道镜才能成功进行此类治疗。