Szendrödi Julia, Roden Michael
Klinische Abteilung für Endokrinologie und Stoffwechsel, Universitätsklinik für Innere Medizin III, Medizinische Universität Wien, Wien, Osterreich.
Acta Med Austriaca. 2004;31(4):98-111.
The adipose tissue stores excess energy but also produces a series of substances including cytokines (adipocytokines) which participate in regulatory processes. The physiologic and pathophysiologic relevance of these factors has only recently been described in more detail. Defects in adiponectin as well as overproduction of free fatty acids play an important role in the development of insulin resistance typical for obesity. Rare forms of obesity or lipodystrophy can now be explained by defects in the leptin system. The contribution of adipose tissue and its cytokines to the relationship between inflammation and the metabolic syndrome is currently under investigation.
脂肪组织储存多余能量，但也会产生一系列物质，包括参与调节过程的细胞因子（脂肪细胞因子）。这些因子的生理和病理生理相关性直到最近才得到更详细的描述。脂联素缺陷以及游离脂肪酸的过量产生在肥胖典型的胰岛素抵抗发展中起重要作用。现在，罕见的肥胖形式或脂肪营养不良可以通过瘦素系统的缺陷来解释。脂肪组织及其细胞因子对炎症与代谢综合征之间关系的作用目前正在研究中。
