van de Waterbeemd Han
Pfizer Global Research and Development, PDM, Sandwich Laboratories, IPC 664, Ramsgate Road, Sandwich, Kent CT13 9NJ, U.K.
Basic Clin Pharmacol Toxicol. 2005 Mar;96(3):162-6. doi: 10.1111/j.1742-7843.2005.pto960304.x.
The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption and for volume of distribution. The prediction of these human pharmacokinetic parameters can be based on proper combination of simple physicochemical measurements. In the future in vitro screens most likely will be combined with in silico assessments of various ADME properties leading to the concept of in combo screening in drug discovery.
中高通量体外药物吸收、分布、代谢、排泄（ADME）特性筛选的发展，是为了满足药物代谢科学家应对化学和生物学进展提出的更高要求。这里将讨论两个领域，即口服吸收筛选和分布容积筛选。这些人体药代动力学参数的预测可以基于简单物理化学测量的适当组合。未来的体外筛选很可能会与各种ADME特性的计算机模拟评估相结合，从而形成药物发现中的联合筛选概念。
