Bener Abdulbari, Eihakeem Amr A M, Abdulhadi Khaled
Department of Medical Statistics and Epidemiology, Hamad General Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, State of Qatar.
Int J Pediatr Otorhinolaryngol. 2005 Mar;69(3):327-33. doi: 10.1016/j.ijporl.2004.10.004. Epub 2004 Dec 1.
Hearing loss (HL) and its complications appear to be increasingly common in developing countries. Previous studies have supported the association between hearing loss and consanguinity.
The aim of the present study was to determine the frequency of hearing loss and its association with consanguinity among Qatari population. In addition, correlation between hearing loss and Rhesus (Rh) blood groups has been investigated.
This is a cross-sectional study.
The study conducted at the Hamad General Hospital, Hamad Medical Corporation.
Total sample of 2800 infants screened and 2277 subjects were eligible to be included in the study.
The neonatal screening for hearing loss was conducted from January 2003 to November 2003 among all the 2800 infants born during that period. Some of them were admitted to neonatal intensive care unit (NICU). The hearing loss was screened using otoacoustic emission (Garson Stadler Incorporation, GSI-70), auditory brain stem responses (ABR) and tympanogram.
Out of 2277 infant screened, the prevalence of hearing loss was (119/2277) 5.2%. The prevalence of HL was more common in boys (2.7%) than in girls (2.5%). We did not find any statistical significance differences between genders with the respect of HL. Parental consanguinity was more common among HL cases compared with non-HL 60.5% versus 25.3% (p < 0.0001). Family history of hearing loss did not show any differences between the two groups. 4.2% versus 4.3%. Risk factors like caesarean section, prenatal smoking and prenatal high blood pressure did not show any significant differences between the two groups. However, admission to NICU is associated with increase prevalence of HL 8.4% versus 4.4% (p = 0.043). The present study revealed that strong correlation between hearing loss, consanguineous (r = 0.217, p < 0.01), father education level illiterate (r = 0.293, p < 0.01), mothers consanguineous (r = 0.206, p < 0.01), mothers educational level illiterate (r = 0.228, p < 0.01), mother blood group positive (r = 0.476, p < 0.01), family history of HL among first or second degree of relatives (r = 0.620, p < 0.01) and father hypertension (r = 0.570, p < 0.01). Furthermore, a significant correlation between hearing loss and Rh blood groups has been discovered.
The present study was directed at determining the prevalence and risk factors of HL in the infant population of Qatar. The data revealed that parental consanguinity was more common among hearing loss cases. There is a strong correlation between hearing loss and baby's age.
在发展中国家，听力损失（HL）及其并发症似乎越来越普遍。先前的研究支持听力损失与近亲结婚之间的关联。
本研究的目的是确定卡塔尔人群中听力损失的发生率及其与近亲结婚的关联。此外，还研究了听力损失与恒河猴（Rh）血型之间的相关性。
这是一项横断面研究。
该研究在哈马德医疗公司的哈马德综合医院进行。
共筛查了2800名婴儿，其中2277名符合纳入研究的条件。
2003年1月至2003年11月期间，对该时期出生的2800名婴儿进行了听力损失的新生儿筛查。其中一些婴儿被送入新生儿重症监护病房（NICU）。使用耳声发射（Garson Stadler公司，GSI-70）、听性脑干反应（ABR）和鼓室图进行听力损失筛查。
在筛查的2277名婴儿中，听力损失的患病率为（119/2277）5.2%。HL在男孩中的患病率（2.7%）高于女孩（2.5%）。在HL方面，我们未发现性别之间存在任何统计学显著差异。与非HL病例相比，HL病例中父母近亲结婚更为常见，分别为60.5%和25.3%（p < 0.0001）。两组之间听力损失家族史无差异，分别为4.2%和4.3%。剖宫产、产前吸烟和产前高血压等危险因素在两组之间未显示出任何显著差异。然而，入住NICU与HL患病率增加相关，分别为8.4%和4.4%（p = 0.043）。本研究表明，听力损失与近亲结婚（r = 0.217，p < 0.01）、父亲文盲教育水平（r = 0.293，p < 0.01）、母亲近亲结婚（r = 0.206，p < 0.01）、母亲文盲教育水平（r = 0.228，p < 0.01）、母亲血型阳性（r = 0.476，p < 0.01）、一级或二级亲属中有HL家族史（r = 0.620，p < 0.01）和父亲高血压（r = 0.570，p < 0.01）之间存在强相关性。此外，还发现听力损失与Rh血型之间存在显著相关性。
本研究旨在确定卡塔尔婴儿人群中HL的患病率和危险因素。数据显示，听力损失病例中父母近亲结婚更为常见。听力损失与婴儿年龄之间存在强相关性。
