Lasmézas Corinne Ida, Comoy Emmanuel, Hawkins Stephen, Herzog Christian, Mouthon Franck, Konold Timm, Auvré Frédéric, Correia Evelyne, Lescoutra-Etchegaray Nathalie, Salès Nicole, Wells Gerald, Brown Paul, Deslys Jean-Philippe
Commissariat à l'Energie Atomique/Direction des Sciences du Vivant/Départment de Recherche Médicale, 18 Route du Panorama, 92265 Fontenay-aux-Roses, France.
Lancet. 2005;365(9461):781-3. doi: 10.1016/S0140-6736(05)17985-9.
The uncertain extent of human exposure to bovine spongiform encephalopathy (BSE)--which can lead to variant Creutzfeldt-Jakob disease (vCJD)--is compounded by incomplete knowledge about the efficiency of oral infection and the magnitude of any bovine-to-human biological barrier to transmission. We therefore investigated oral transmission of BSE to non-human primates. We gave two macaques a 5 g oral dose of brain homogenate from a BSE-infected cow. One macaque developed vCJD-like neurological disease 60 months after exposure, whereas the other remained free of disease at 76 months. On the basis of these findings and data from other studies, we made a preliminary estimate of the food exposure risk for man, which provides additional assurance that existing public health measures can prevent transmission of BSE to man.
人类接触牛海绵状脑病（BSE，可导致变异型克雅氏病（vCJD））的不确定程度，因对经口感染效率以及牛与人之间任何生物传播屏障的大小了解不全面而更加复杂。因此，我们研究了BSE向非人灵长类动物的经口传播情况。我们给两只猕猴经口投喂了5克来自一头感染BSE奶牛的脑匀浆。一只猕猴在接触后60个月出现了类似vCJD的神经疾病，而另一只在76个月时仍未患病。基于这些发现以及其他研究的数据，我们对人类的食物暴露风险做了初步估计，这为现有公共卫生措施能够预防BSE传播给人类提供了更多保障。
