Rodriguez A-M, Elabd C, Amri Ez-Z, Ailhaud G, Dani C
Faculté des Sciences, Centre de Biochimie, Institut de Recherche Signalisation, Biologie du Developpement et Cancer, UMR 6543 CNRS, Parc Valrose, 06108 Nice cedex 2, France.
Biochimie. 2005 Jan;87(1):125-8. doi: 10.1016/j.biochi.2004.11.007.
Multipotent stem cells constitute an unlimited source of differentiated cells that could be used in pharmacological studies and in medicine. Recently, several publications have reported that adipose tissue contains a population of cells able to differentiate into different cell types including adipocytes, osteoblasts, myoblasts, and chondroblasts. More recently, stem cells with a multi-lineage potential at the single cell level have been isolated from human adipose tissue. These cells, called human Multipotent Adipose-Derived Stem (hMADS) cells, have been established in culture and interestingly, maintain their characteristics with long-term passaging. The adipocyte differentiation of hMADS cells has been thoroughly studied and differentiated cells exhibit the unique feature of human adipocytes. Finally, potential applications of stem cells isolated from adipose tissue in medicine will be discussed.
多能干细胞构成了一个无限的分化细胞来源，可用于药理学研究和医学领域。最近，有几篇出版物报道，脂肪组织中含有一群能够分化为不同细胞类型的细胞，包括脂肪细胞、成骨细胞、成肌细胞和软骨细胞。最近，已经从人类脂肪组织中分离出了在单细胞水平上具有多谱系潜能的干细胞。这些细胞被称为人类多能脂肪来源干细胞（hMADS），已在培养中建立，有趣的是，它们在长期传代过程中仍保持其特性。hMADS细胞的脂肪细胞分化已得到深入研究，分化后的细胞表现出人类脂肪细胞的独特特征。最后，将讨论从脂肪组织中分离出的干细胞在医学上的潜在应用。
