Department of Biology, Clarkson University, Potsdam, NY, United States.
Front Public Health. 2023 Jul 6;11:1156749. doi: 10.3389/fpubh.2023.1156749. eCollection 2023.
Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's declining function and the development of pain, it may affect one's physical health, mental health, and socioeconomic status. Most of the intervertebral disc degeneration (IVDD) therapies today focus on the symptoms of low back pain rather than the underlying etiology or mechanical function of the disc. The deteriorated disc is typically not restored by conservative or surgical therapies that largely focus on correcting symptoms and structural abnormalities. To enhance the clinical outcome and the quality of life of a patient, several therapeutic modalities have been created. In this review, we discuss genetic and environmental causes of IVDD and describe promising modern endogenous and exogenous therapeutic approaches including their applicability and relevance to the degeneration process.
椎间盘退变（IVD）是衰老的正常组成部分。由于脊柱功能下降和疼痛的发展，它可能会影响一个人的身体健康、心理健康和社会经济地位。目前大多数椎间盘退变（IVDD）的治疗方法都集中在腰痛的症状上，而不是椎间盘的潜在病因或机械功能上。保守或手术治疗主要集中在纠正症状和结构异常上，通常不能恢复恶化的椎间盘。为了提高患者的临床疗效和生活质量，已经开发了几种治疗方法。在这篇综述中，我们讨论了 IVDD 的遗传和环境原因，并描述了有前途的现代内源性和外源性治疗方法，包括它们在退变过程中的适用性和相关性。
