Narayanan Sriram, Surendranath Kalpana, Bora Namrata, Surolia Avadhesha, Karande Anjali A
Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India.
FEBS Lett. 2005 Feb 28;579(6):1324-31. doi: 10.1016/j.febslet.2005.01.038.
Ribosome inactivating proteins (RIPs) are protein toxins that are of plant or microbial origin that inhibit protein synthesis by inactivating ribosomes. Recent studies suggest that RIPs are also capable of inducing cell death by apoptosis. Though many reports are available on cell death induced by RIPs, the mechanism involved is not well studied. Comparison of pathways of apoptosis and cellular events induced by various RIPs suggests a central role played by mitochondria, probably acting as an integrator of cellular stress and cell death. The purpose of this review is to compare the various apoptotic pathways that may be involved and propose a general pathway in RIP-induced cell death.
核糖体失活蛋白（RIPs）是一类源自植物或微生物的蛋白质毒素，它们通过使核糖体失活来抑制蛋白质合成。最近的研究表明，RIPs也能够通过凋亡诱导细胞死亡。尽管有许多关于RIPs诱导细胞死亡的报道，但其中涉及的机制尚未得到充分研究。对各种RIPs诱导的凋亡途径和细胞事件的比较表明，线粒体发挥着核心作用，可能作为细胞应激和细胞死亡的整合者。本综述的目的是比较可能涉及的各种凋亡途径，并提出RIPs诱导细胞死亡的一般途径。
