Shiffman Saul
Pinney Associates, 201 North Craig Street, Suite 320, Pittsburgh, PA 15213, USA.
Drug Alcohol Depend. 2005 Mar 7;77(3):311-4. doi: 10.1016/j.drugalcdep.2004.08.026.
Nicotine replacement therapy (NRT) has been proven to be effective in heterogeneous groups of smokers. However, analyses have not specifically examined efficacy among light smokers (< or =15 cigarettes per day). The objective of this study is to assess the efficacy of a nicotine lozenge in light smokers.
We conducted a secondary analysis of a randomized, placebo-controlled clinical trial contrasting active 2mg nicotine lozenge with placebo, and contrasting light smokers (< or =15 cigarettes per day) with moderate-heavy smokers (>15 cigarettes per day). Participants were 917 smokers who smoked their first cigarette >30 min after waking, and were randomized to active (n = 459) or placebo (n = 458) lozenge. Biochemically verified continuous abstinence was measured at 6 weeks and 1 year.
Nicotine lozenge significantly increased quit rates relative to placebo at 6 weeks (45.7% versus 31.1%; OR = 1.9 [1.3-2.8]) and at 1 year (19.2% versus 10.0%; OR = 2.3 [1.3-4.0]) among light smokers. Efficacy among light smokers did not differ from that among heavier smokers (ps>0.50).
The nicotine lozenge is effective for light smokers.
尼古丁替代疗法（NRT）已被证明在不同类型的吸烟者群体中有效。然而，此前的分析并未专门研究轻度吸烟者（每天吸烟≤15支）的疗效。本研究的目的是评估尼古丁含片对轻度吸烟者的疗效。
我们对一项随机、安慰剂对照临床试验进行了二次分析，该试验对比了活性2mg尼古丁含片与安慰剂，并对比了轻度吸烟者（每天吸烟≤15支）和中度-重度吸烟者（每天吸烟>15支）。参与者为917名吸烟者，他们在醒来后30分钟以上吸第一支烟，并被随机分配到活性组（n = 459）或安慰剂组（n = 458）。在6周和1年时测量经生化验证的持续戒烟情况。
在轻度吸烟者中，尼古丁含片在6周时（45.7%对31.1%；OR = 1.9 [1.3 - 2.8]）和1年时（19.2%对10.0%；OR = 2.3 [1.3 - 4.0]）相对于安慰剂显著提高了戒烟率。轻度吸烟者的疗效与重度吸烟者的疗效没有差异（p>0.50）。
尼古丁含片对轻度吸烟者有效。
