Shiffman Saul, Di Marino Michael E, Pillitteri Janine L
Pinney Associates, Pittsburgh, PA, USA; University of Pittsburgh, Smoking Research Group, Pittsburgh, PA 15213, USA.
J Subst Abuse Treat. 2005 Jan;28(1):49-55. doi: 10.1016/j.jsat.2004.10.006.
The efficacy of nicotine replacement therapy (NRT) among very heavy and highly dependent smokers was examined in a secondary analysis of two randomized clinical trials of NRT. In the first trial, smokers were assigned to active patch (n=249) or placebo (n=253) plus intensive behavioral treatment. In the second trial, smokers were assigned to active 4-mg nicotine lozenge (n=450) or placebo (n=451) plus brief behavioral treatment. Nicotine patch and lozenge significantly increased 6-month continuous abstinence quit rates in both very heavy (>or=40 cigarettes per day) and highly dependent (Fagerström Tolerance Questionnaire or Fagerström Test for Nicotine Dependence score >7) smokers. The effect of active NRT treatment did not differ significantly by smoking rate or nicotine dependence, with the exception that the nicotine patch was significantly more effective than placebo in highly dependent smokers. The nicotine patch and lozenge are effective (vs. placebo) even in heavy and highly dependent smokers.
在两项尼古丁替代疗法（NRT）随机临床试验的二次分析中，研究了NRT在重度且高度依赖吸烟人群中的疗效。在第一项试验中，吸烟者被分配至活性贴片组（n = 249）或安慰剂组（n = 253），并接受强化行为治疗。在第二项试验中，吸烟者被分配至活性4毫克尼古丁含片组（n = 450）或安慰剂组（n = 451），并接受简短行为治疗。尼古丁贴片和含片显著提高了重度（每天吸≥40支香烟）和高度依赖（法格斯特罗姆耐受问卷或法格斯特罗姆尼古丁依赖测试得分>7）吸烟者的6个月持续戒烟率。活性NRT治疗的效果在吸烟率或尼古丁依赖方面无显著差异，但尼古丁贴片在高度依赖吸烟者中比安慰剂显著更有效。即使在重度和高度依赖吸烟人群中，尼古丁贴片和含片也比安慰剂更有效。
