Partridge Linda, Gems David, Withers Dominic J
UCL Centre for Research on Ageing, Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, United Kingdom.
Cell. 2005 Feb 25;120(4):461-72. doi: 10.1016/j.cell.2005.01.026.
A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.
寿命和繁殖力呈负相关的繁殖成本普遍存在。胰岛素/胰岛素样生长因子信号（IIS）通路的突变和饮食限制（DR）可以延长模式生物的寿命，但并不总是降低繁殖力，这表明寿命和繁殖力之间的联系并非不可避免。通过阐明饮食限制和IIS影响这两个性状的机制，将有助于理解繁殖成本的分子基础。
