Pontillo Nicholas, Lyu Yang
Department of Molecular Biology and Biochemistry, Rutgers, The State University of New Jersey, Piscataway, NJ 08854-8000, USA.
Biomolecules. 2025 Jan 28;15(2):187. doi: 10.3390/biom15020187.
Perception alone can, in some cases, be sufficient to modulate aging and longevity. These influences on aging are perhaps mediated by changes in motivational states that regulate metabolism and physiology to impact health. Simple invertebrate models uniquely enable detailed dissection of integrative pathways linking perceptions to aging and remain the leading systems for advancing this field. Over the past 25 years, studies using the fruit fly and the nematode have demonstrated that sensory cues, such as those related to food or mating, can influence aging independently of the physical acts associated with them. In this review, we highlight recent advancements in these invertebrate models, focusing on two key areas of progress: (i) the discovery of lifespan modulation driven by novel sensory cues across multiple modalities, including non-sexual social experience, light, and dietary choices; and (ii) the assignment of new aging-regulation functions to specific neurons downstream of sensory perception. The latter offers an exciting first glimpse at the neuronal circuits integrating sensory cues, motivational states, physiology, and aging.
在某些情况下，仅感知就足以调节衰老和寿命。这些对衰老的影响可能是由调节新陈代谢和生理机能以影响健康的动机状态变化介导的。简单的无脊椎动物模型独特地能够详细剖析将感知与衰老联系起来的整合途径，并且仍然是推动该领域发展的主要系统。在过去25年中，使用果蝇和线虫的研究表明，诸如与食物或交配相关的感官线索，可以独立于与之相关的身体行为来影响衰老。在这篇综述中，我们重点介绍这些无脊椎动物模型的最新进展，重点关注两个关键进展领域：（i）发现由多种模式的新型感官线索驱动的寿命调节，包括非性社会经验、光和饮食选择；（ii）将新的衰老调节功能赋予感觉感知下游的特定神经元。后者首次令人兴奋地瞥见了整合感官线索、动机状态、生理机能和衰老的神经回路。
