Bessho K, Tagawa T, Murata M
Department of Oral and Maxillofacial Surgery, Mie University School of Medicine, Japan.
J Oral Maxillofac Surg. 1992 May;50(5):496-501. doi: 10.1016/s0278-2391(10)80323-4.
Bone matrix-derived bone morphogenetic protein (BMP) was extracted from bovine, porcine, rabbit, Sprague-Dawley rat, and Wistar rat bone and purified. The purified fractions all had similar molecular weights and induced new bone in 3 weeks when implanted into muscle pouches of Wistar rats. Bone matrix-derived BMP is believed to consist of subunits and that of different animal origin to contain the same fraction with BMP activity.
从牛、猪、兔、斯普拉格-道利大鼠和Wistar大鼠的骨骼中提取并纯化骨基质衍生的骨形态发生蛋白(BMP)。纯化后的组分分子量均相似,植入Wistar大鼠的肌肉袋中3周后可诱导新骨形成。骨基质衍生的BMP被认为由亚基组成,且不同动物来源的BMP含有相同的具有BMP活性的组分。