脑转移瘤的病理生物学
Pathobiology of brain metastases.
作者信息
Nathoo N, Chahlavi A, Barnett G H, Toms S A
机构信息
Brain Tumor Institute, Taussig Cancer Center and Department of Neurosurgery, Cleveland Clinic Foundation, Cleveland, Ohio 44122, USA.
出版信息
J Clin Pathol. 2005 Mar;58(3):237-42. doi: 10.1136/jcp.2003.013623.
Abstract
Brain metastasis is a major cause of systemic cancer morbidity and mortality. Many factors participate in the development and maintenance of brain metastases. The survival of the metastasis depends upon crucial interactions between tumour cells and the brain microenvironment during its development at the new site. This review focuses on the pathobiological mechanisms involved in the establishment and regulation of brain metastases. Developments in molecular biology have vastly expanded our knowledge about the mechanisms of invasion, proliferation, metastatic cell signalling, and angiogenesis in brain metastases. Advances in this understanding of the pathobiology of brain metastasis may lead to novel targeted treatment paradigms and a better prognosis for patients with brain metastatic disease.
摘要
脑转移是系统性癌症发病和死亡的主要原因。许多因素参与了脑转移的发生和维持。转移灶的存活取决于肿瘤细胞在新部位生长过程中与脑微环境之间的关键相互作用。本综述聚焦于脑转移发生和调控所涉及的病理生物学机制。分子生物学的发展极大地扩展了我们对脑转移中侵袭、增殖、转移细胞信号传导和血管生成机制的认识。对脑转移病理生物学认识的进展可能会带来新的靶向治疗模式，并改善脑转移性疾病患者的预后。
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