Janner A
Institute for Theoretical Physics, Radboud University, Toernooiveld, 6525 ED Nijmegen, The Netherlands.
Acta Crystallogr D Biol Crystallogr. 2005 Mar;61(Pt 3):269-77. doi: 10.1107/S0907444904032718. Epub 2005 Feb 24.
Three cases are considered of protein-DNA (or protein-RNA) complexes with a strongly correlated structure based on symmetry. In the first the symmetry of the nucleic acid is the determinant element, the second contains a dominant protein and an adaptive DNA/RNA and in the third a perturbed symmetry arises from elements of both components. The first situation is exemplified by the filamentous bacteriophage Pf1 in a low- and high-temperature state. The Pyrococcus abyssi Sm core and the trp RNA-binding attenuation protein are examples of the second situation. Finally, the nucleosome core particle represents the cooperative compromise between histone and DNA. In all the cases, the strong correlation in the structure is based on polygrammal scaling relations and on a molecular polygonal form lattice which depends on a single parameter.
考虑了三例具有基于对称性的强相关结构的蛋白质 - DNA（或蛋白质 - RNA）复合物。第一例中，核酸的对称性是决定性因素；第二例包含一个占主导地位的蛋白质和一个适应性DNA/RNA；第三例中，扰动对称性由两个组分的元素共同产生。第一种情况以处于低温和高温状态的丝状噬菌体Pf1为例。嗜热栖热菌Sm核心和色氨酸RNA结合衰减蛋白是第二种情况的例子。最后，核小体核心颗粒代表了组蛋白和DNA之间的协同折衷。在所有这些情况中，结构中的强相关性基于多语法标度关系以及依赖于单个参数的分子多边形形式晶格。
