Wolfram Swen, Raederstorff Daniel, Wang Ying, Teixeira Sandra R, Elste Volker, Weber Peter
DSM Nutritional Products Ltd, Department of Human Nutrition and Health, Basel, Switzerland.
Ann Nutr Metab. 2005 Jan-Feb;49(1):54-63. doi: 10.1159/000084178. Epub 2005 Feb 25.
This study investigated the antiobesity effects of TEAVIGO, a product providing the most abundant green tea catechin, epigallocatechin gallate (EGCG), in a pure form. Two models of diet-induced obesity and an in vitro adipocyte differentiation assay were employed.
Prevention and regression of diet-induced obesity by dietary supplementation with EGCG was studied in C57BL/6J mice and Sprague-Dawley rats, respectively. Expression of genes regulating lipid metabolism was assessed in adipose tissue. The effects of EGCG on adipocyte differentiation were investigated in vitro.
In C57BL/6J mice, EGCG supplementation prevented diet-induced increases in body weight and in fed state plasma levels of glucose, triglycerides, and leptin. EGCG decreased subcutaneous and epididymal adipose tissue weights. Supplementation of EGCG reversed the established obesity in Sprague-Dawley rats. Fatty acid synthase and acetyl-CoA carboxylase-1 mRNA levels were markedly decreased in adipose tissue of EGCG-supplemented mice. EGCG dose dependently inhibited adipocyte differentiation in vitro.
This study shows for the first time that supplementation with the most abundant green tea polyphenol, EGCG, abolishes diet-induced obesity. This effect is at least partly mediated via a direct influence on adipose tissue. Thus, dietary supplementation with EGCG should be considered as a valuable natural treatment option for obesity.
本研究调查了TEAVIGO的抗肥胖作用，TEAVIGO是一种以纯形式提供最丰富的绿茶儿茶素——表没食子儿茶素没食子酸酯（EGCG）的产品。采用了两种饮食诱导肥胖模型和一项体外脂肪细胞分化试验。
分别在C57BL/6J小鼠和Sprague-Dawley大鼠中研究了通过饮食补充EGCG对饮食诱导肥胖的预防和逆转作用。评估了脂肪组织中调节脂质代谢的基因表达。在体外研究了EGCG对脂肪细胞分化的影响。
在C57BL/6J小鼠中，补充EGCG可预防饮食诱导的体重增加以及进食状态下血浆葡萄糖、甘油三酯和瘦素水平的升高。EGCG降低了皮下和附睾脂肪组织的重量。补充EGCG可逆转Sprague-Dawley大鼠已形成的肥胖。在补充EGCG的小鼠的脂肪组织中，脂肪酸合酶和乙酰辅酶A羧化酶-1的mRNA水平显著降低。EGCG在体外剂量依赖性地抑制脂肪细胞分化。
本研究首次表明，补充最丰富的绿茶多酚EGCG可消除饮食诱导的肥胖。这种作用至少部分是通过对脂肪组织的直接影响介导的。因此，饮食补充EGCG应被视为一种有价值的肥胖自然治疗选择。
