Kumar Dinender, Kamp Timothy J, LeWinter Martin M
Department of Medicine, University of Vermont, Burlington, VT, 05446, USA.
Coron Artery Dis. 2005 Mar;16(2):111-6. doi: 10.1097/00019501-200503000-00006.
Many forms of heart disease are associated with the loss of cardiomyocytes both via apoptosis or necrosis, and despite the recent identification of resident cardiac stem cells, the native capacity for renewal and repair is inadequate. Cell transplantation strategies have emerged as a potential therapeutic approach for repairing injured myocardium. Many different cell types including embryonic stem cells have been transplanted in myocardial infarction (MI) models with resulting improvement in myocardial function. Here, we review the current state of knowledge with regard to the potential of embryonic stem (ES) cells to differentiate into cardiomyocytes in the embryonic stem cell derived-embryoid body (EB) in vitro system as well as for myocardial regeneration following myocardial infarction.
许多形式的心脏病都与心肌细胞通过凋亡或坏死而丧失有关，尽管最近发现了心脏驻留干细胞，但心脏自身的更新和修复能力仍不足。细胞移植策略已成为修复受损心肌的一种潜在治疗方法。包括胚胎干细胞在内的许多不同细胞类型已被移植到心肌梗死（MI）模型中，从而改善了心肌功能。在此，我们综述了关于胚胎干细胞（ES）在体外胚胎干细胞衍生的胚状体（EB）系统中分化为心肌细胞的潜力以及心肌梗死后心肌再生的现有知识状况。
