Department of Molecular Cell Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands.
Curr Med Chem. 2012;19(35):5993-6002. doi: 10.2174/092986712804485935.
After myocardial infarction, the lost healthy myocardium is replaced by non-contractile scar tissue which may lead to the development of heart failure and death. There is no curative therapy for the irreversible myocardial cell loss. This review will give an overview of the current options to restore the contractile force of the heart: the different stem cell sources as therapeutic agents in cardiac repair as well as more novel approaches like the activation of endogenous cell populations, the use of paracrine factors and engineered heart tissue.
心肌梗死后，失去的健康心肌被非收缩性瘢痕组织所取代，这可能导致心力衰竭和死亡。对于不可逆转的心肌细胞丢失，目前尚无治愈疗法。本综述将概述恢复心脏收缩力的当前选择：不同的干细胞来源作为心脏修复的治疗剂，以及更新颖的方法，如激活内源性细胞群、使用旁分泌因子和工程化心脏组织。
