Domitrz Izabela
Katedra i Klinika Neurologii, Akademia Medyczna w Warszawie, ul. Banacha 1a, 02-097 Warsaw, Poland.
Neurol Neurochir Pol. 2005 Jan-Feb;39(1):77-9.
Hypnic headache is a rare type of primary short-lasting headache related to sleep. The pathogenesis of hypnic headache still remains unknown, but it may be a chronobiological disturbance or a response to a pineal circadian irregularity in which melatonin may play a role in resynchronizing biological rhythms to lifestyle. It is a moderate headache that appears during sleep with almost an alarm clock regularity and lasts up to 60 minutes. The headache is boring, unilateral or with diffuse location. Lithium carbonate and flunarizine show the best efficacy, caffeine and melatonin may also be useful. The author describes two cases of hypnic headache, which were effectively treated. A 45-year-old woman was treated with flunarizine and melatonin and a 65-year-old man was treated with flunarizine. The efficacy of flunarizine may be associated with the activation of D2 receptor and the added treatment with melatonin may hasten the good effect similar to that seen in our patient.
睡眠性头痛是一种罕见的与睡眠相关的原发性短期头痛。睡眠性头痛的发病机制尚不清楚，但可能是一种生物钟紊乱或对松果体昼夜节律异常的反应，其中褪黑素可能在使生物节律与生活方式重新同步中发挥作用。这是一种中度头痛，在睡眠期间出现，几乎像闹钟一样规律，持续长达60分钟。头痛为闷痛，单侧或呈弥漫性分布。碳酸锂和氟桂利嗪疗效最佳，咖啡因和褪黑素可能也有用。作者描述了两例睡眠性头痛病例，均得到有效治疗。一名45岁女性接受了氟桂利嗪和褪黑素治疗，一名65岁男性接受了氟桂利嗪治疗。氟桂利嗪的疗效可能与D2受体的激活有关，添加褪黑素治疗可能会加速产生良好效果，就像我们的患者那样。
