Toyoda Hidenori, Kumada Takashi, Kiriyama Seiki, Sone Yasuhiro, Tanikawa Makoto, Hisanaga Yasuhiro, Kuzuya Teiji, Honda Takashi, Hayashi Kazuhiko, Nakano Isao, Katano Yoshiaki, Goto Hidemi
Department of Gastroenterology, Ogaki Municipal Hospital, Ogaki, Nagoya, Japan.
Clin Infect Dis. 2005 Mar 15;40(6):e49-54. doi: 10.1086/428128. Epub 2005 Feb 18.
Changes in hepatitis C virus (HCV) antibody status were followed for 10 years after the eradication of HCV by interferon (IFN) therapy in 30 patients with chronic hepatitis C who showed a sustained virological response.
HCV core antibody titer, third-generation HCV recombinant immunoblot assay (RIBA) grade (measuring the presence of antibodies for core, NS3, NS4, and NS5 antigens), and genotype-specific antibodies to the HCV NS4 region were measured annually with commercially available kits for these antibodies.
For grade of HCV antibody determined by RIBA, the most significant decrease was observed with anti-NS5 antibody, followed by anti-NS4, anti-NS3, and anti-core antibodies, in that order. Tests for anti-NS5 and anti-NS4 antibodies had negative results in almost 50% of patients 10 years after eradication of HCV. In contrast, the results of tests for anti-core antibody were still markedly positive in most patients. However, anti-core antibody titer decreased continuously during the 10-year follow-up period. Antibodies to the NS4 region specific for HCV genotypes 1 and 2 also decreased during the follow-up period. Differences in the rate at which antibody titers decreased were observed between antibodies for genotypes 1 and 2; as a consequence, the serological type of HCV changed during the follow-up period in some patients.
HCV antibody titer appears to continue to decrease during the 10 years after eradication of HCV by IFN therapy.
对30例经干扰素（IFN）治疗获得持续病毒学应答的慢性丙型肝炎患者，在丙型肝炎病毒（HCV）根除后随访10年观察HCV抗体状态的变化。
每年使用市售试剂盒检测HCV核心抗体滴度、第三代HCV重组免疫印迹分析（RIBA）分级（检测核心、NS3、NS4和NS5抗原的抗体存在情况）以及针对HCV NS4区域的基因型特异性抗体。
对于通过RIBA确定的HCV抗体分级，抗NS5抗体下降最为显著，其次依次为抗NS4、抗NS3和抗核心抗体。HCV根除10年后，几乎50%的患者抗NS5和抗NS4抗体检测结果为阴性。相比之下，大多数患者抗核心抗体检测结果仍显著为阳性。然而，在10年随访期间抗核心抗体滴度持续下降。随访期间，HCV 1型和2型特异性NS4区域的抗体也有所下降。观察到1型和2型抗体滴度下降速率存在差异；因此，部分患者随访期间HCV血清型发生了变化。
经IFN治疗根除HCV后10年内，HCV抗体滴度似乎持续下降。
