[认知诱发电位在评估哌甲酯治疗注意缺陷多动障碍儿童疗效中的价值]
[The value of cognitive evoked potentials in assessing the effectiveness of methylphenidate treatment in children with attention deficit hyperactivity disorder].
作者信息
Idiazábal-Alecha M A, Rodríguez-Vázquez S, Guerrero-Gallo D, Vicent-Sardinero X
机构信息
Hospital Universitari del Mar, 08003 Barcelona, Espana.
出版信息
Rev Neurol. 2005 Jan 15;40 Suppl 1:S37-42.
AIM
To investigate the changes of the latency and amplitude of P300 in relation to methylphenidate (MPH) medication.
SUBJECTS AND METHODS
36 children with attention deficit hyperactivity disorder (ADHD) and 18 children as control group were tested with an auditory and visual oddball paradigm both before and 1.5 h after a single dose trial of MPH.
RESULTS
MPH increased the amplitude and the latency of the visual and auditory P300 component In the ADHD group the latency of the P300 component was longer and the amplitude smaller than in the control group.
CONCLUSION
These results suggests that MPH acts to improve processing of cognitive information in children with ADHD where no differences with normal children are present.
目的
研究哌甲酯（MPH）用药与P300潜伏期及波幅变化的关系。
对象与方法
36例注意缺陷多动障碍（ADHD）患儿及18例儿童作为对照组，在单次MPH给药试验前及给药后1.5小时，采用听觉和视觉oddball范式进行测试。
结果
MPH增加了视觉和听觉P300成分的波幅和潜伏期。在ADHD组中，P300成分的潜伏期比对照组更长，波幅更小。
结论
这些结果表明，MPH可改善ADHD患儿认知信息的处理，在这方面与正常儿童无差异。
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