Kemner Chantal, Jonkman Lisa M, Kenemans J Leon, Böcker Koen B E, Verbaten Marinus N, Van Engeland Herman
Department of Child and Adolescent Psychiatry, University Medical Center Utrecht, The Netherlands.
Biol Psychiatry. 2004 Apr 1;55(7):776-8. doi: 10.1016/j.biopsych.2003.12.007.
The aim of this study was to determine 1) whether abnormal auditory selective attention in children with attention-deficit/hyperactivity disorder (ADHD), as reflected in the processing negativity (PN) of the event-related potential, is related to impaired frontal functioning; and 2) how methylphenidate (MPh) affects attentional functioning in ADHD.
Sources of electrical brain activity were estimated in healthy control children, in ADHD children without medication, and in children with ADHD during a placebo-controlled medication trial involving MPh.
The source models showed that the PN is generated in the auditory cortex. Children with ADHD showed less activity related to selective attention in this brain region. Administration of MPh resulted in more frontally located sources.
The results showed no evidence for an important role of the frontal cortex in abnormalities in selective attention in children with ADHD. Also, the data did not indicate that MPh normalizes brain activity in these children.
本研究的目的是确定：1）注意缺陷多动障碍（ADHD）儿童的异常听觉选择性注意，如事件相关电位的加工负波（PN）所反映的，是否与额叶功能受损有关；以及2）哌甲酯（MPh）如何影响ADHD儿童的注意力功能。
在健康对照儿童、未用药的ADHD儿童以及在涉及MPh的安慰剂对照药物试验期间的ADHD儿童中估计脑电活动源。
源模型显示PN在听觉皮层产生。ADHD儿童在该脑区与选择性注意相关的活动较少。给予MPh导致源更位于额叶。
结果表明没有证据支持额叶皮层在ADHD儿童选择性注意异常中起重要作用。此外，数据也未表明MPh能使这些儿童的脑活动正常化。
