Ashtari Manzar, Kumra Sanjiv, Bhaskar Shree L, Clarke Tana, Thaden Emily, Cervellione Kelly L, Rhinewine Joseph, Kane John M, Adesman Andrew, Milanaik Ruth, Maytal Joseph, Diamond Alan, Szeszko Philip, Ardekani Babak A
Departments of Radiology, North Shore Long Island Jewish Medical Center, New Hyde Park, NY 11040, USA.
Biol Psychiatry. 2005 Mar 1;57(5):448-55. doi: 10.1016/j.biopsych.2004.11.047.
The purpose of this study was to explore whether there are white matter (WM) abnormalities in children with attention-deficit/hyperactivity disorder (ADHD) using diffusion tensor imaging. Based upon the literature, we predicted decreased fractional anisotropy (FA) findings in the frontal and cerebellar regions.
Eighteen patients with ADHD and 15 age- and gender-matched healthy volunteers received DTI assessments. Fractional anisotropy maps of WM were compared between groups with a voxelwise analysis after intersubject registration to Talairach space.
Children with ADHD had decreased FA in areas that have been implicated in the pathophysiology of ADHD: right premotor, right striatal, right cerebral peduncle, left middle cerebellar peduncle, left cerebellum, and left parieto-occipital areas.
These preliminary data support the hypothesis that alterations in brain WM integrity in frontal and cerebellar regions occur in ADHD. The pattern of decreased FA might implicate the corticopontocerebellar circuit in the pathophysiology of ADHD.
本研究旨在利用扩散张量成像探索注意缺陷多动障碍（ADHD）患儿是否存在白质（WM）异常。基于文献，我们预测额叶和小脑区域的分数各向异性（FA）值会降低。
18例ADHD患者和15名年龄及性别匹配的健康志愿者接受了DTI评估。在将个体间图像配准到Talairach空间后，通过体素分析比较两组之间WM的分数各向异性图。
ADHD患儿在一些与ADHD病理生理学相关的区域FA值降低，这些区域包括右侧运动前区、右侧纹状体、右侧大脑脚、左侧小脑中脚、左侧小脑以及左侧顶枕区。
这些初步数据支持了ADHD患者额叶和小脑区域脑白质完整性发生改变这一假说。FA值降低的模式可能提示皮质脑桥小脑环路在ADHD病理生理学中的作用。
