Hickie Ian, Naismith Sharon, Ward Philip B, Turner Keelin, Scott Elizabeth, Mitchell Philip, Wilhelm Kay, Parker Gordon
Brain & Mind Research Institute, PO Box M160, Missenden Road, NSW Australia.
Br J Psychiatry. 2005 Mar;186:197-202. doi: 10.1192/bjp.186.3.197.
Hippocampal volume reduction has been reported inconsistently in people with major depression.
To evaluate the interrelationships between hippocampal volumes, memory and key clinical, vascular and genetic risk factors.
Totals of 66 people with depression and 20 control participants underwent magnetic resonance imaging and clinical assessment. Measures of depression severity, psychomotor retardation, verbal and visual memory and vascular and specific genetic risk factors were collected.
Reduced hippocampal volumes occurred in older people with depression, those with both early-onset and late-onset disorders and those with the melancholic subtype. Reduced hippocampal volumes were associated with deficits in visual and verbal memory performance.
Although reduced hippocampal volumes are most pronounced in late-onset depression, older people with early-onset disorders also display volume changes and memory loss. No clear vascular or genetic risk factors explain these findings. Hippocampal volume changes may explain how depression emerges as a risk factor to dementia.
在重度抑郁症患者中，海马体体积减小的报道并不一致。
评估海马体体积、记忆力与关键临床、血管及遗传风险因素之间的相互关系。
66名抑郁症患者和20名对照参与者接受了磁共振成像和临床评估。收集了抑郁严重程度、精神运动迟缓、言语和视觉记忆以及血管和特定遗传风险因素的测量数据。
老年抑郁症患者、早发性和晚发性抑郁症患者以及忧郁型亚型患者的海马体体积减小。海马体体积减小与视觉和言语记忆表现缺陷有关。
尽管海马体体积减小在晚发性抑郁症中最为明显，但早发性抑郁症的老年患者也表现出海马体体积变化和记忆丧失。没有明确的血管或遗传风险因素能解释这些发现。海马体体积变化可能解释了抑郁症如何成为痴呆症的一个风险因素。
