Robertson Emma, Jones Ian, Haque Sayeed, Holder Roger, Craddock Nick
Neuropsychiatric Genetics Unit, Department of Psychological Medicine, School of Medicine, Cardiff University, Heath Park, Cardiff CF14 4XN, Wales, UK.
Br J Psychiatry. 2005 Mar;186:258-9. doi: 10.1192/bjp.186.3.258.
The clinical value of information on the risk of future psychiatric illness in women who have experienced puerperal (post-partum) psychosis has been limited by inconsistencies in terminology and nosology. Here we report rates of subsequent puerperal and non-puerperal episodes, in a well characterised sample of women diagnosed with clearly defined bipolar affective puerperal psychosis (n=103). Out of 54 women having further children, 31(57%; 95% CI 44-69) experienced an additional puerperal psychotic episode, and 64 of 103 women (62%; 95% CI 52-71) experienced a non-puerperal affective episode during the follow-up period (mean duration 9 years). A history of bipolar episodes prior to the puerperal psychosis did not predict risk following subsequent pregnancies, but positive family history of mental illness predicted shorter time to non-puerperal relapse.
术语和疾病分类的不一致限制了有关经历过产褥期（产后）精神病的女性未来患精神疾病风险信息的临床价值。在此，我们报告了在确诊为明确的双相情感性产褥期精神病的特征明确的女性样本（n = 103）中，后续产褥期和非产褥期发作的发生率。在54名有更多子女的女性中，31名（57%；95%CI 44 - 69）经历了额外的产褥期精神病发作，103名女性中有64名（62%；95%CI 52 - 71）在随访期间（平均持续时间9年）经历了非产褥期情感发作。产褥期精神病之前的双相发作史并不能预测后续怀孕后的风险，但精神疾病的阳性家族史预测非产褥期复发的时间更短。
