Ma Zuwei, Kotaki Masaya, Inai Ryuji, Ramakrishna Seeram
Nanoscience and Nanotechnology Initiative, Division of Bioengineering, National University of Singapore, Singapore.
Tissue Eng. 2005 Jan-Feb;11(1-2):101-9. doi: 10.1089/ten.2005.11.101.
Tissue-engineering scaffolds should be analogous to native extracellular matrix (ECM) in terms of both chemical composition and physical structure. Polymeric nanofiber matrix is similar, with its nanoscaled nonwoven fibrous ECM proteins, and thus is a candidate ECM-mimetic material. Techniques such as electrospinning to produce polymeric nanofibers have stimulated researchers to explore the application of nanofiber matrix as a tissue-engineering scaffold. This review covers the preparation and modification of polymeric nanofiber matrix in the development of future tissue-engineering scaffolds. Major emphasis is also given to the development and applications of aligned, core shell-structured, or surface-functionalized polymer nanofibers. The potential application of polymer nanofibers extends far beyond tissue engineering. Owing to their high surface area, functionalized polymer nanofibers will find broad applications as drug delivery carriers, biosensors, and molecular filtration membranes in future.
组织工程支架在化学成分和物理结构方面应类似于天然细胞外基质（ECM）。聚合物纳米纤维基质与之相似，具有纳米级非织造纤维状ECM蛋白，因此是一种模拟ECM的候选材料。诸如静电纺丝制备聚合物纳米纤维的技术激发了研究人员探索纳米纤维基质作为组织工程支架的应用。本文综述了聚合物纳米纤维基质在未来组织工程支架开发中的制备和改性。还重点介绍了排列整齐、核壳结构或表面功能化聚合物纳米纤维的开发与应用。聚合物纳米纤维的潜在应用远远超出了组织工程领域。由于其高比表面积，功能化聚合物纳米纤维未来将在药物递送载体、生物传感器和分子过滤膜等方面有广泛应用。
