酸性钙小体——从细菌到人类都保守存在。
Acidocalcisomes - conserved from bacteria to man.
作者信息
Docampo Roberto, de Souza Wanderley, Miranda Kildare, Rohloff Peter, Moreno Silvia N J
机构信息
Department of Cellular Biology and Center for Tropical and Global Emerging Diseases, University of Georgia, Athens, Georgia 30602, USA.
出版信息
Nat Rev Microbiol. 2005 Mar;3(3):251-61. doi: 10.1038/nrmicro1097.
Recent work has shown that acidocalcisomes, which are electron-dense acidic organelles rich in calcium and polyphosphate, are the only organelles that have been conserved during evolution from prokaryotes to eukaryotes. Acidocalcisomes were first described in trypanosomatids and have been characterized in most detail in these species. Acidocalcisomes have been linked with several functions, including storage of cations and phosphorus, polyphosphate metabolism, calcium homeostasis, maintenance of intracellular pH homeostasis and osmoregulation. Here, we review acidocalcisome ultrastructure, composition and function in different trypanosomatids and other organisms.
最近的研究表明，酸性钙小体是富含钙和多聚磷酸盐的电子致密酸性细胞器，是从原核生物到真核生物进化过程中唯一保守的细胞器。酸性钙小体最早在锥虫中被描述，并且在这些物种中得到了最详细的表征。酸性钙小体与多种功能相关，包括阳离子和磷的储存、多聚磷酸盐代谢、钙稳态、细胞内pH稳态的维持和渗透调节。在这里，我们综述了不同锥虫和其他生物体中酸性钙小体的超微结构、组成和功能。
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