Laboratório de Imunologia Básica e Aplicada, Department of Immunology, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro 21941-902, Brazil.
Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Viruses. 2024 Oct 15;16(10):1612. doi: 10.3390/v16101612.
Monocytes and macrophages are part of innate immunity and constitute the first line of defense against pathogens. Bone marrow-derived monocytes circulate in the bloodstream for one to three days and then typically migrate into tissues, where they differentiate into macrophages. Circulatory monocytes represent 5% of the nucleated cells in normal adult blood. Following differentiation, macrophages are distributed into various tissues and organs to take residence and maintain body homeostasis. Emerging evidence has highlighted the critical role of monocytes/macrophages in oncogenic viral infections, mainly their crucial functions in viral persistence and disease progression. These findings open opportunities to target innate immunity in the context of oncogenic viruses and to explore their potential as immunotherapies.
单核细胞和巨噬细胞是先天免疫的一部分，构成了抵御病原体的第一道防线。骨髓来源的单核细胞在血液中循环 1 至 3 天，然后通常迁移到组织中分化为巨噬细胞。循环单核细胞占正常成人血液有核细胞的 5%。分化后，巨噬细胞分布到各种组织和器官中，以驻留并维持体内平衡。新出现的证据强调了单核细胞/巨噬细胞在致癌性病毒感染中的关键作用，主要是它们在病毒持续存在和疾病进展中的关键功能。这些发现为针对致癌病毒的固有免疫提供了机会，并探索了它们作为免疫疗法的潜力。
