Dell'Acqua S, Parlati E, Lucisano A, Plotti G, Serri F, Bompiani A
J Perinat Med. 1979;7(3):149-60. doi: 10.1515/jpme.1979.7.3.149.
It is well known that in pregnancy dehydroepiandrosterone-sulphate (DHEAS) (90% synthetized by the fetal adrenals, 10% by the maternal ones) is converted into estrogens mainly in the placenta. In order to evaluate the steroid metabolizing capacity of the placental enzymatic complex under load conditions, a test was devised based upon a rapid introduction of 200 mg of DHEAS into the amniotic compartment during the third trimester of gestation. The purpose of the present investigation was to establish the clinical utility of such a test in comparison with the simple urinary estrogen determination test.
众所周知，在孕期，硫酸脱氢表雄酮（DHEAS）（90%由胎儿肾上腺合成，10%由母体肾上腺合成）主要在胎盘内转化为雌激素。为了评估负荷条件下胎盘酶复合物的类固醇代谢能力，设计了一项试验，即在妊娠晚期向羊膜腔快速注入200毫克DHEAS。本研究的目的是确定该试验相对于简单的尿雌激素测定试验的临床实用性。
