Jagodic M, Vrhovec I, Borstnar S, Cufer T
Institute of Oncology, SI-1000 Ljubljana, Slovenia.
Neoplasma. 2005;52(1):1-9.
None of the established prognostic factors in breast cancer (BC) is able to determine the final outcome with certainity. Tumor biological factors involved in tumor invasion and metastasis, such as cathepsins and proteins of u-PA system, have been put forward in the recent literature as strong novel prognostic factors in BC. We therefore evaluated prognostic and predictive value of cathepsin-D (CD) and cathepsin-L (CL) in 715 operable BC patients. CD and CL were determined in tumor extracts using immunoradiometric and ELISA assays, respectively. During follow-up (median 37 months), 151 (21%) patients relapsed. In a multivariate analysis of disease-free survival (DFS), CL (p=0.04), nodal status (p<0.001) and hormone receptor status (p<0.001) were the only independent significant prognostic factors. CL thus provided independent prognostic information on DFS and could also predict a response to adjuvant chemotherapy (ChT), while CD had no significant prognostic and predictive impact.
乳腺癌（BC）中已有的预后因素均无法确切地确定最终结果。近期文献提出，参与肿瘤侵袭和转移的肿瘤生物学因素，如组织蛋白酶和尿激酶型纤溶酶原激活物（u-PA）系统的蛋白质，是BC中强有力的新预后因素。因此，我们评估了组织蛋白酶-D（CD）和组织蛋白酶-L（CL）在715例可手术BC患者中的预后和预测价值。分别使用免疫放射分析和酶联免疫吸附测定法在肿瘤提取物中测定CD和CL。在随访期间（中位时间37个月），151例（21%）患者复发。在无病生存期（DFS）的多变量分析中，CL（p=0.04）、淋巴结状态（p<0.001）和激素受体状态（p<0.001）是仅有的独立显著预后因素。因此，CL提供了关于DFS的独立预后信息，并且还可以预测对辅助化疗（ChT）的反应，而CD没有显著的预后和预测影响。
