Kreiger Portia A, Okada Yoshifumi, Simon Scott, Rorke Lucy B, Louis David N, Golden Jeffrey A
Department of Pathology, Abramson Research Center, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.
Acta Neuropathol. 2005 Apr;109(4):387-92. doi: 10.1007/s00401-004-0976-2. Epub 2005 Mar 1.
Pediatric oligodendrogliomas are rare neoplasms and have not been characterized extensively either pathologically or genetically. Given the recent interest in the significance of chromosomal losses in predicting the clinical course and in establishing uniform diagnoses of adult oligodendrogliomas, we reviewed the pathological and clinical features of a series of pediatric oligodendrogliomas and determined their 1p and 19q status using fluorescence in situ hybridization. Of 19 tumors originally diagnosed as oligodendroglioma, 7 were oligodendroglioma, 3 were anaplastic oligodendroglioma, 3 were oligoastrocytoma, and 6 were reclassified. Only one tumor, an anaplastic oligodendroglioma, had 1p loss; none had 19q loss. The single patient whose tumor had 1p loss did not have a particularly favorable clinical course. These results suggest that pediatric oligodendrogliomas arise by molecular alterations distinct from adult oligodendrogliomas, and such molecular alterations do not hold immediate promise as an adjunct to the diagnosis of pediatric oligodendrogliomas.
小儿少突胶质细胞瘤是罕见肿瘤，在病理或基因方面均未得到广泛的特征描述。鉴于近期对染色体缺失在预测成人少突胶质细胞瘤临床病程及建立统一诊断方面的重要性颇感兴趣，我们回顾了一系列小儿少突胶质细胞瘤的病理和临床特征，并采用荧光原位杂交法确定其1p和19q状态。在最初诊断为少突胶质细胞瘤的19例肿瘤中，7例为少突胶质细胞瘤，3例为间变性少突胶质细胞瘤，3例为少突星形细胞瘤，6例被重新分类。仅1例间变性少突胶质细胞瘤存在1p缺失；无一例存在19q缺失。肿瘤有1p缺失的唯一患者临床病程并非特别良好。这些结果表明，小儿少突胶质细胞瘤的发生是由不同于成人少突胶质细胞瘤的分子改变所致，且此类分子改变对小儿少突胶质细胞瘤的诊断并无直接帮助。
