Brandenburg J H, Kirkham W, Koschkee D
Department of Surgery, University of Wisconsin, Madison.
Laryngoscope. 1992 May;102(5):495-500. doi: 10.1288/00005537-199205000-00005.
Since 1987, the authors have used a new technique for the augmentation and medialization of the paralyzed vocal cord. Eleven patients with paralyzed vocal cords and one patient with a surgical defect of the vocal cord have been treated with intracordal injections of autogenous fat harvested by suction from the abdominal wall. Treatment efficacy was evaluated by both subjective and objective (videostroboscopic) analyses. Patient follow-up has ranged from 5 to 42 months. All patients showed significant improvement in voice characteristics. Marked reduction in air flow and increased vocal intensity were observed. Correction of glottic insufficiency has been lasting, indicating that the implanted fat cells are viable. At this time, there has been no evidence of loss of vocal cord substance. The natural qualities of autogenous fat appear to make it an excellent alternative to Teflon or collagen. The fat is readily available, and easily harvested and injected. A larger patient population and longer follow-up periods will help determine if these initial findings are consistent.
自1987年以来，作者采用了一种用于麻痹声带增大及内移的新技术。11例声带麻痹患者和1例声带手术缺损患者接受了经腹壁抽吸获取的自体脂肪声带内注射治疗。通过主观和客观（频闪喉镜）分析对治疗效果进行评估。患者随访时间为5至42个月。所有患者的嗓音特征均有显著改善。观察到气流显著减少，发声强度增加。声门闭合不全的矫正效果持久，表明植入的脂肪细胞存活。目前，尚无声带实质损失的证据。自体脂肪的天然特性似乎使其成为替代特氟龙或胶原蛋白的理想选择。脂肪容易获取，易于采集和注射。更多的患者群体和更长的随访期将有助于确定这些初步发现是否一致。
