Buonuomo V, Ruggiero A, Rando G, D'Urzo C, Manzoni C, Pintus C
Department of Pediatrics, Catholic University of Medicine and Surgery, Rome, Italy.
Pediatr Hematol Oncol. 2004 Dec;21(8):731-8. doi: 10.1080/08880010490515029.
Paraganglioma is a rare neuroendocrine neoplasm observed in patients of all ages but it has not been characterized in children. The authors describe a retroperitoneal paraganglioma diagnosed by chance in an 11-year-old boy. Many aspects of retroperitoneal paraganglioma are still under investigation. The treatment of choice is radical resection. Surgery may be possible following chemotherapeutic debulking with cyclophosphamide, vincristine, and dacarbazine. 131I-MIBG radiotherapy has proved increasingly useful in reducing the pain associated with disseminated disease and also in facilitating surgical resection in cases that appear inoperable. Conventional radiotherapy is purely palliative and used to reduce the pain of bone metastases.
副神经节瘤是一种罕见的神经内分泌肿瘤，可见于各年龄段患者，但在儿童中尚无特征描述。作者报告了一名11岁男孩偶然诊断出的腹膜后副神经节瘤。腹膜后副神经节瘤的许多方面仍在研究中。首选治疗方法是根治性切除。在使用环磷酰胺、长春新碱和达卡巴嗪进行化疗减瘤后，可能可行手术。131I-间碘苄胍放射治疗已被证明在减轻与播散性疾病相关的疼痛以及在看似无法手术的病例中促进手术切除方面越来越有用。传统放疗纯粹是姑息性的，用于减轻骨转移的疼痛。
