Wright Barry, Brzozowski Andrzej Marek, Calvert Elizabeth, Farnworth Helen, Goodall David M, Holbrook Ian, Imrie Gregg, Jordan Jo, Kelly Anne, Miles Jeremy, Smith Rob, Town Joel
Child and Adolescent Mental Health Unit, University of York, Limetrees, Shipton Road, York YO30 5RF, UK.
Dev Med Child Neurol. 2005 Mar;47(3):190-2. doi: 10.1017/s0012162205000344.
To test whether the presence of indolyl-3-acryloylglycine (IAG) is associated with autism, we analyzed urine from population-based, blinded cohorts. All children in York, UK with autism spectrum disorders (ASDs), diagnosed using ICD-10 research diagnostic criteria, were invited to participate. Fifty-six children on the autism spectrum (mean age 9y 8mo, SD 3y 8mo; 79% male) agreed to participate, as did 155 children without ASDs (mean age 10y, SD 3y 2mo; 54% male) in mainstream and special schools (56 of whom were age-, sex-, and school-matched to children with ASDs). IAG was found at similar levels in the urine of all children, whether IAG concentrations or IAG:creatinine ratios were compared. There was no significant difference between the ASD and the comparison group, and no difference between children at mainstream schools and those at special schools. There is no association between presence of IAG in urine and autism; therefore, it is unlikely to be of help either diagnostically or as a basis for recommending therapeutic intervention with dietary manipulation. The significance of the presence of IAG in urine has yet to be determined.
为了检验吲哚 - 3 - 丙烯酰甘氨酸（IAG）的存在是否与自闭症相关，我们分析了基于人群的盲法队列研究中的尿液样本。所有使用国际疾病分类第10版（ICD - 10）研究诊断标准确诊为自闭症谱系障碍（ASD）的英国约克郡儿童均受邀参与。56名自闭症谱系儿童（平均年龄9岁8个月，标准差3岁8个月；79%为男性）同意参与，主流学校和特殊学校的155名无ASD儿童（平均年龄10岁，标准差3岁2个月；54%为男性）也同意参与（其中56名在年龄、性别和学校方面与ASD儿童匹配）。无论比较IAG浓度还是IAG与肌酐的比值，所有儿童尿液中IAG的含量水平相似。ASD组与对照组之间无显著差异，主流学校儿童与特殊学校儿童之间也无差异。尿液中IAG的存在与自闭症之间无关联；因此，它不太可能在诊断方面有所帮助，也不太可能作为通过饮食调整进行治疗干预推荐的依据。尿液中IAG存在的意义尚待确定。
